Job voices a desperate cry about the extreme fragility of human life, contrasting God's infinite power with the absolute vulnerability of the physical body. He wonders about the logic of punishing a creature that is already doomed to decay.
The primary approach among commentators is that Job is asking God why He bothers to target him. The human body is weak and lowly, destined to rot away entirely like a useless, moth-eaten piece of clothing. Because of this inherent weakness, it seems beneath God's dignity to aggressively pursue such an insignificant being [רש״י, מצודת דוד, ביאור שטיינזלץ]. This argument builds on Job's earlier comparisons of himself to a blown leaf or dry straw. Since human beings are already given a short life full of natural suffering and inevitable death, God does not need to show His might against them. Therefore, it is inappropriate to add further punishment for the mistakes of a person's youth when the ultimate penalty of death is already guaranteed [רמב״ן].
The images of decay carry a deeper truth about human vulnerability. On one hand, rotting matter represents an internal breakdown. The human body naturally carries the seeds of its own decay and is built to eventually fail from the inside out. On the other hand, a garment eaten by a moth represents destruction caused by an outside force. Together, these ideas show that human beings are constantly exposed to total ruin, threatened equally by their own internal biology and by external dangers [מלבי״ם].
Taking a completely different direction, another perspective views this argument as a debate about reincarnation and physical pain. In this view, the physical body is merely a temporary piece of clothing for the soul. The body will naturally waste away, whether it breaks down slowly in old age or is destroyed suddenly in its youth. Job protests the unfairness of his situation, asking why his current body must endure severe suffering to fix the sins his soul committed while living in a completely different body in a past life. Since his current physical form is just temporary matter that will soon disappear, it holds no true guilt and should not have to bear the punishment [אלשיך].