The sheer power of the creature renders all human weaponry completely useless, as it stands its ground without a trace of fear [מצודת דוד, מלבי״ם]. When attacked from afar, it remains entirely unfazed. The primary approach among commentators is that arrows, poetically viewed as offspring emerging from the womb of a bow, cannot make the beast flee [מצודת ציון, מלבי״ם]. Another perspective suggests that the focus is on the human attacker; the archer wielding the weapon is entirely powerless to drive the creature away [רש״י, רמב״ן]. Whether it is the projectile or the person firing it, the attack ends in total failure.
This futility extends beyond arrows to heavy stones hurled with intense force from slings [מצודת ציון, רלב״ג]. Even massive boulders, the kind typically used in siege warfare to shatter fortress walls, fail to leave a mark. To the creature, these heavy projectiles feel as light and harmless as pieces of straw [רש״י, מצודת דוד, מלבי״ם, ביאור שטיינזלץ]. The impact is entirely meaningless, as though one were simply tossing dried grass against an immovable force.