The ultimate answer to the painful question of why bad people often succeed lies in understanding the source of true life. While the wicked may appear to prosper temporarily, their choice to disconnect from the Divine inevitably leads to their own destruction. This reality stands in sharp contrast to the eternal bond the righteous share with their Creator.
Those who willingly move away from God are destined to lose everything, both in this current life and for eternity, forfeiting their place in His presence [מאירי, ביאור שטיינזלץ, מצודת דוד, אלשיך]. This ultimate downfall occurs for two primary reasons [מלבי״ם]. First, it is a simple, natural consequence. Because God is the life force sustaining all creation, pulling away from Him is like pulling away from life itself; the person naturally brings about their own end. Second, their downfall is not just a passive result but an active punishment brought about by divine providence, which completely uproots and destroys them [מצודת ציון, מאירי, ביאור שטיינזלץ]. This severe destruction is compared to the absolute and final isolation of a person afflicted with leprosy, symbolizing the total social and spiritual disconnection of the sinner [תורה תמימה].
This active destruction targets anyone who breaks faith and strays. The primary approach among commentators is that this straying does not necessarily refer to a physical act of betrayal. Instead, it represents the very act of turning away, deviating, and separating from God's paths [רש״י, רד״ק, מצודת ציון, ביאור שטיינזלץ]. It paints a picture of an individual who completely abandons God's domain in both thought and action [אבן עזרא], much like a spouse who abandons the boundaries of a faithful marriage [מצודת ציון].
The comparison to infidelity is highly intentional. Just as marital betrayal is a severe offense that typically brings swift and strict consequences, it serves as a powerful warning regarding all who do wrong [אלשיך]. Even if God appears patient and allows certain wicked individuals to prosper for a time, He will ultimately hold accountable anyone who strays from His path. In the end, they will be entirely cut off from the divine source. This final separation strips them of the privilege to seek shelter under God's protection [מאירי] and guarantees they will have no share or connection with Him after the physical body dies [רד״ק].