A profound contrast exists between the fear of mortal men and the reverence for God. When a person is filled with genuine awe for the Divine, the threats of powerful enemies quickly lose their significance. Powerful leaders and those wielding worldly authority pursued the author relentlessly [אבן עזרא, ביאור שטיינזלץ]. Historically, these figures represent King Saul and his loyalists, or perhaps Absalom [רד״ק, מאירי]. This intense persecution was entirely baseless, driven by no actual wrongdoing or sin that would justify such hostility [אלשיך, מצודת דוד].
Despite the looming threat from these rulers, the primary approach among commentators is that an overwhelming fear of God and His commandments completely overshadows any terror caused by human pursuers. As reverence for God grows, the fear of mortals shrinks. It is much like a person standing before a lion, completely unconcerned by the threat of a bee sting [מלבי״ם].
This deep anxiety regarding God's word takes several forms. There is a genuine worry that the endless harassment from enemies might prevent the fulfillment of the Torah [מאירי] or succeed in distancing the author from serving God [רד״ק]. From another perspective, this reverence acts as a strict moral boundary. Even when the opportunity and power existed to strike back at the pursuers, the fear of God's word held back the hand of revenge [מצודת דוד].
Furthermore, this dread is linked to specific divine rebukes. The true source of terror was not the armies chasing him, but harsh prophecies foretelling that disaster would strike from within his own house [רד״ק], or the severe reprimands delivered by Nathan the prophet regarding his personal failings [אלשיך]. Ultimately, an innocent person has no reason to fear mortal enemies; true, profound anxiety only takes root when God's word confronts a person with his own sins [אלשיך].